Muscle relaxant less sedating

CNS depression produces sedation, and the perception of pain could be altered.

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Brief history All three medications are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.

Carisoprodol, cyclobenzaprine and metaxalone are not found to be effective in the treatment of spasticity associated with upper motor neuron syndromes.

In the head to head trial of cyclobenzaprine and carisoprodol, dry mouth was more frequent with cyclobenzaprine (38% vs. Metaxalone has the fewest reported side effects of any skeletal muscle relaxants and appears to be the safest.

Metaxalone is considered to be less sedating in comparison with carisoprodol and cyclobenzaprine.

Meloxicam suspension for members older than 7 years of age will require a prior authorization.

A prior authorization request can be submitted for members older than 7 years of age requiring meloxicam suspension.Metaxalone is contraindicated in drug-induced, hemolytic or other anemias and in significantly impaired renal or hepatic function. When there is no a clearly superior agent, side effect profiles and cost become a significant factor in the selection of muscle relaxers.With the Memorial Day Weekend upon us, I thought it would be a great opportunity to remind patients requiring regular use of opioid therapy, to avoid alcohol as they celebrate and reflect on the sacrifices of heroic veterans past and present, that enable us to celebrate freely.Cyclobenzaprine: Since cyclobenzaprine is closely similar to amitriptyline in chemical structure, some of its effects are similar to the tricyclic antidepressants.Cyclobenzaprine relieves muscle spasms through a central action, possibly at the brain stem level, with no direct action on the neuromuscular junction or the muscle involved. Treatment with the drug reduces pain and tenderness, and improves mobility.Sedation is the most commonly reported adverse effect of muscle relaxants.

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