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Psychomotor disability is a delay in the acquisition of skills requiring mental and muscular activities such head control, sitting up, and walking.
About half of children with cri du chat syndrome were able to dress themselves by age 5 years.
Introduction The disorder was first described in the medical literature in 1963 by doctor Lejeune who named the disorder after the distinctive cat-like cry.
As affected infants age the face may lose its plumpness and become abnormally long and narrow.
Most affected infants also display some degree of psychomotor and intellectual disability.
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NORD gratefully acknowledges Scott Pentiuk MD, Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, and Adam Mezoff, MD, Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, for assistance in the preparation of this report.
Additional symptoms affecting different organ systems of the body can also occur.
Most cases are thought arise from spontaneous (de novo) genetic errors very early in embryonic development.
Common symptoms include a distinctive cry that resembles the mewing of a cat, characteristic facial features, slow growth, and microcephaly, a condition that indicates that head circumference is smaller than would be expected for an infant's age and sex.
Affected children also exhibit delays in the acquisition of skills requiring the coordination of muscular and mental activities (psychomotor disability) and moderate to severe intellectual disability.
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